|
|
| |
New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
 |
100% Natural and Safe Remedy
People Said About Goutezol Gout Treatment
| "week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago |
 |
HOW PEGLOTICASE WORKS
What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS
Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
It has been having a decent degree of success.
Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
|
|
#1 Doctor Recommended Remedy
People Said About Goutezol Gout Relief
| "My big toe was in horrible pain, so i went to emergency room. Dr diagnosed gout in my foot and gave me pain killers. I did some googling and found goutezol. I like that it's natural with no chemicals in it. Ive been taking it for about 6 months and so far no attack, and my doc confirmed lower uric acid in my blood. thank you!" Jeff, NY |
|
In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.
31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.
SIDE EFFECTS
Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.
NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
|
|
|
|
| |
| |
|
|
|
|
|
|
| |
| |
Learn More about Natural Gout Remedy
Gout is a problem that in most of the cases occurs suddenly. That is why it is really hard to prevent it. Doctors can only advice for a low alcohol intake and a healthy diet. Only after its occurrence specialists are able to prescribe a treatment. Treatment for gout is prescribed in order to ease the symptoms that usually consist of extreme pain in the affected joints.
We know two types... 
A common cause of gout is the accumulation of a chemical called uric acid. Uric acid is a normal breakdown product of another chemical called purines. The treatment involves controlling the inflammation, which causes the pain and swelling and ultimately damage to joints. Also, lowering the uric acid level is a logical means to controlling gout.
There is some benefit to avoiding foods that...
Acupressure can provide wonderful relief for gout attacks and it can be used as a complimentary treatment with medication or with other natural remedies like nutritional therapy. Nutritional therapy is type of natural cure for gout that is based on the belief that food contains the natural medicines our body requires in order to obtain and sustain health.
How can nutritional therapy help...
Gout is a fairly old disease, being around for more than two thousand years. Gout is a disease that affects mostly mean, but women can suffer from gout as well, mostly after menopause. Gout is a very hard rheumatic disease, but out off all this type of diseases, gout probably has the best treatment.
There was a myth that said that the cause of gout is too much food and drinks. Nowadays,...
Gout is a painful disease of the joints, which usually affects the big toe first in most people. It is caused by too much uric acid in the blood. Uric acid is formed by the breakdown of chemicals called purines, which can lead to high levels of uric acid and cause many problems such as joint swelling and kidney stones. Normally the uric acid is dissolved in the blood and passes out via the...
medical condition of gout | diet for people with gout | causes of gouty arthritis | low purine diets for gout | what do purines look like | gout home remedies joints |
gout symptoms and treatment
gout symptoms and treatment
gout symptoms and treatment
gout of the elbow
painful big toe joint
preeclampsia uric acid
Alcohol joint pain
gout and chesse
gout remedies
gout remedy
|
|
|
| |
| |
|
|
| |
|
|
|
|
